Monday, November 29, 2010
ABOUT PROFESSOR C HEATHER ASHTON, DM, FRCP
Monday, April 12, 2010
Adverse effects of Benzodiazepines in the elderly.
Excerpt from "The Ashton Manual"
Older people are more sensitive than younger people to the central nervous system depressant effects of benzodiazepines. Benzodiazepines can cause confusion, night wandering, amnesia, ataxia (loss of balance), hangover effects and "pseudodementia" (sometimes wrongly attributed to Alzheimer’s disease) in the elderly and should be avoided wherever possible. Increased sensitivity to benzodiazepines in older people is partly because they metabolise drugs less efficiently than younger people, so that drug effects last longer and drug accumulation readily occurs with regular use. However, even at the same blood concentration, the depressant effects of benzodiazepines are greater in the elderly, possibly because they have fewer brain cells and less reserve brain capacity than younger people.
For these reasons, it is generally advised that, if benzodiazepines are used in the elderly, dosage should be half that recommended for adults, and use (as for adults) should be short-term (2 weeks) only. In addition, benzodiazepines without active metabolites (e.g. oxazepam [Serax], temazepam [Restoril]) are tolerated better than those with slowly eliminated metabolites (e.g. chlordiazepoxide [Librium], nitrazepam [Mogadon]). Equivalent potencies of different benzodiazepines are approximately the same in older as in younger people (Refer to table 1 in the manual).
Thursday, September 3, 2009
Tranquilizers and Antidepressants: Know the Side Effects
Author Shirley Trickett treats you as a complete person, not just a combination of physical symptoms. With clarity and compassion, she offers you the guidance and support necessary to manage your withdrawal. Her constant reassurance - mixed with sound advice on getting support from friends, family and recovery groups - will help you find the strength to persevere towards health and freedom. Above all, her approach is optimistic, always reminding you that you will win through to recovery.
This new updated version has Shirley's added information about possible reasons for prolonged protracted withdrawal, insight into new therapies, updated information on SSRI withdrawal and much much more.
'Shirley Trickett's book on coming off tranquilzers and antidepressants is literally a 'life saver.' It is the one book which helps people cope with drug withdrawal by explanations and sensible advice. I trusted it and feel I would not have come through without it. It helped me to live again.
Sylvia Flynn, Newcastle, UK
'I felt you were speaking directly to me in your tranquilizer book. I was so tired of being told I was suffering from 'executive stress' or even once, that it was my age! I was only forty seven at the time. Thank you.'
Anthony, London
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Thursday, August 27, 2009
The Accidental Addict
by Di Porritt & Di Russell
"The Accidental Addict is and excellent self-help book, offering support, hope and encouragement as well as a full description of benzo symptoms and personal stories of recovery. This book is a very important resource for people having problems discontinuing benzodiazepines."